A group of blues enthusiasts and musicians started meeting in 2006 with the idea of forming a Blues Society in Central Mississippi. These persons included: Carol Marble, Jesse Robinson, and Peggy Brown as the core early organization. There was not an official group in Central Mississippi organized around promoting blues music. That same year, the group formally organized itself and designated the organization as the Central Mississippi Blues Society. The organization moved to establish itself legally incorporating under the Laws of the State of Mississippi and by obtaining a tax identification number from the Internal Revenue Service and begun to develop its By-Laws and strategies for operating. The organization appointed its first president in 2006.

In 2007, the appointed president resigned and the group appointed a leading member to serve out the term until the By-Laws were established and formal elections could be held. During the same year, the By-Laws were adopted and a formal election held to elect the first group of officers. Since that time, the organization has developed several programs, participated in community activities, and established a format for promoting live blues and related music.